Phosphodiesterase 4 inhibitors
Phosphodiesterase 4 (PDE4) inhibitors are a class of drugs used to treat psoriatic arthritis. PDE4 inhibitors work by inhibiting the enzyme phosphodiesterase 4, responsible for the breakdown of cyclic adenosine monophosphate (cAMP).
PDE4 inhibitors block the enzyme, resulting in an accumulation of cAMP and a decrease in the production of proinflammatory mediators. This leads to an overall reduction in inflammation and, in turn, an improvement in the symptoms of psoriatic arthritis.
In addition to their anti-inflammatory properties, PDE4 inhibitors have also been found to help reduce pain and improve physical function. This makes them an excellent choice for those with moderate to severe psoriatic arthritis seeking an effective, long-term treatment option.